Evaluation and Contribution of Major Chromosomal Abnormalities in Couples with Recurrent Miscarriage

Background: Pregnancy loss is a common phenomenon. Most of the pregnancy losses which happen in the first and second trimesters are caused by chromosomal abnormalities. Repeated pregnancy loss is an extremely stressful condition for both the partners and physicians because it is difficult to find a reason behind it. Materials and Methods: Cytogenetic analysis was performed according to standard methods on lymphocyte cultured cells obtained from the patient peripheral blood. In order to assess the frequency and nature of chromosomal aberrations that contribute to the occurrence of reproductive failure, we investigated 200 couples (400 individuals). Clinical diagnostic indications for chromosome analysis was recurrent abortion (at least three) were studied. The ANOVA test was used for statistical evaluation. The level of p<0.05 was considered as significance. Results: Most of the patients had 3 repeated abortions (66.6%).Cytogenetic analysis performed on 200 couples and karyotype of 5% of them were abnormal. These include translocation in 7 cases and sex chromosomal mosaicism in one case. Conclusion: The present study demonstrates the importance of cytogenetic analysis in elucidating the recurrent miscarriage etiology, and enables healthcare professionals to properly conduct genetic counseling, allowing couples to make correct decisions about their reproductive life.